The historical development of automated hemapheresis

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Abstract
Many studies in the early twentieth century involved attempts to separate white blood cells from whole blood for further examination and experimentation as well as for the treatment of neutropenic patients. In the 1950s, the need to use blood and its derivatives efficiently produced the first apparatus to separate blood continuously in a closed system. The prototypes of present-day continuous flow blood cell separators were developed in the 1960s.