Clonidine and Ketanserin Both Are Effective Treatment for Postanesthetic Shivering

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Abstract
Although meperidine is an effective treatment of postanesthetic shivering, its mechanism of action remains unknown. Investigation of other drugs might help clarify the mechanisms by which shivering can be controlled. Accordingly, we investigated the efficacy of clonidine, an α2-adrenergic agonist, and ketanserin, a 5-hydroxytryptamine antagonist, in treating postanesthetic shivering. First, 54 patients shivering after general anesthesia were allocated randomly to receive an intravenous bolus of saline, 150 µg clonidine, or 10 mg ketanserin. A second study explored the dose-dependence of clonidine. Forty shivering patients were given saline or clonidine, 37.5, 75, or 150 µg. Clonidine (150 µg) and ketanserin (10 mg) both are effective treatment for postanesthetic shivering. The effect of clonidine on shivering is dose-dependent: whereas 37.5 µg had no effect, 75 µg clonidine stopped shivering within 5 min.

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