Pulmonary Disease and Hair-Spray Polymers: A Disputed Relationship

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Abstract
Massive exposure of experimental animals to a vinylalkylether/maleic ester copolymer hair spray by inhalation did not produce granulomatous disease as described in alleged human cases. Intratracheal instillation of hair-spray solids also failed to reproduce the syndrome. In alleged cases of hair-spray thesaurosis, the connecting link was the presence of intracytoplasmic granules stained by the periodic acid-Schiff method and said to be particles of hair-spray resin. However, similar granules were found in a number of diverse pulmonary disorders in patients who had not been exposed to hair sprays, and the general staining characteristics of several hair-spray polymers did not correspond with those of the granules found in claimed instances of thesaurosis.