N1-Glucosides as urinary metabolites of sulphadimidine, sulphamerazine and sulphamethoxazole
- 1 July 1988
- journal article
- research article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 13 (3) , 177-183
- https://doi.org/10.1007/bf03189937
Abstract
The synthesis and cbaracterisationof the N1-β-D glucosides of the three title sulphonamides are described, and these conjugates are shown, by means of HPLC and MS, to be minor urinary metabolites of these drugs.This publication has 11 references indexed in Scilit:
- Simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetylsulphamethoxazole in serum and urine by high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1981
- Phase-Transfer Catalyzed Synthesis of Acetylated Aryl β-D-Glucopyranosides and Aryl β-D-GalactopyranosidesSynthesis, 1981
- METABOLIC-FATE OF PHENOBARBITAL IN MAN - N-GLUCOSIDE FORMATION1979
- High-pressure Liquid Chromatographic Separation, Identification, and Determination of Sulfa Drugs and Their Metabolites in UrineJournal of Pharmaceutical Sciences, 1976
- Synthesis of Morphine-3-GlucuronideSynthetic Communications, 1975
- The metabolism of four sulphonamides in cowsBiochemical Journal, 1973
- Determination of pharmacokinetic parameters for rapid and slow acetylators of sulphadimidineJournal of Pharmacy and Pharmacology, 1972
- Determination of pharmacokinetic parameters for urinary excretion of sulphafurazole under normal and controlled alkaline urine conditionsJournal of Pharmacy and Pharmacology, 1970
- The acetylation of sulfamethazine and sulfamethoxypyridazine by human subjectsClinical Pharmacology & Therapeutics, 1968
- The structure of the glucuronide of sulphadimethoxine formed in manBiochemical Journal, 1965