Susceptibility and Resistance to Viral Leukemogenesis in the Mouse. III. Effect of Added Thymus Tissue From a Susceptible Strain Upon the Response of Two Resistant Strains2

Publisher Website
Google Scholar
Abstract
The induction of lymphoid leukemia by the BALB/Tennantleukemia (B/T-L) virus was increased from 50 percent to 80 to 100 percent (with no shortening in latent period) in small numbers of BALB/c adults by the simultaneous introduction with the virus of trocar-implanted thymus tissue, or of free thymus cells, from susceptible BALB/c sucklings. Addition of free BALB/c thymus cells to B/T-L virus inoculums also increased leukemogenesis in the highly resistant C57BR/cd strain, from 9 percent (with an average latent period of 14.5 months) to 30 percent (with an average latent period of 6.5 months). BALB-thymus-associated lymphoid leukemias thus induced in C578R mice were transplantable to C578R but not to BALB/c adults. The “BR-th/T-L” virus recovered from these leukemias manifested a broadened host range, as compared to original B/T-L filtrates. Leukemogenesis by the virus was not enhanced, however, in sucklings of the resistant C3HeB/Fe strain when thymus tissue or free thymus cells were similarly transferred from BALB/c sucklings.

This publication has 0 references indexed in Scilit: