Enantioselective Synthesis of 3-Oxoesters and Carboxylic Acids as Polyfunctional Small Building Blocks with a Quaternary Stereogenic Center
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (11) , 897-900
- https://doi.org/10.1055/s-1992-21533
Abstract
Polyfunctional 2-substituted 3-oxoesters 4 and carboxylic acids 6 bearing a quaternary stereogenic center are synthesized in good overall yields and high enantiomeric excesses via SAMP/-RAMP-hydrazones. The absolute configuration is confirmed by X-ray structure analysis of 3-oxoester 4i and carboxylic acid 6a.Keywords
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