Aggression and open-field activity of lead-exposed mice

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Abstract
Blood lead levels were increased 11 to 18 times in mice that ingested a 5 mg/ml solution of lead acetate for 2 or 4 weeks, with no effect on weight gain. Although the lead treatment produced neither mortality nor obvious abnormalities, it nevertheless inhibited the development of isolationinduced aggression which was characteristic of control mice. This effect cannot be explained on the basis of changes in motor activity.