NADH Measured by Laser Fluorimetry in Skeletal Muscle in McArdle's Disease

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Abstract
To the Editor: It has recently been reported that monitoring of NADH fluorescence can be used for the detection of abnormalities in oxidative metabolism in the human myocardium.1 NAD is reduced to NADH during the oxidative catabolism of various substrates consumed by muscles. NADH oxidation regenerates NAD and produces ATP mainly in the mitochondria. In patients with McArdle's disease (muscular phosphorylase deficiency), muscle glycogen cannot be broken down, and it has been suggested that one of the most important consequences is a deficiency in oxidative substrates, resulting in a limited production of NADH.2 We used a laser fluorimeter3 to perform . . .