Synthesis of α-Acetyl Lactones; Access to 14-Membered Bislactones by Attempts at Direct Ring Closure
- 1 June 2002
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 2002 (06) , 0957-0961
- https://doi.org/10.1055/s-2002-31907
Abstract
α-Acetyl lactones are accessed by Mukaiyama-Claisen reactions. Attempts at direct 7-membered ring closure, by either intramolecular alkylation of 4-iodobutyl acetoacetate or olefin metathesis from allyl 2-allyl-3-oxobutanoate, afford exclusively dimeric 14-membered ring products instead of the expected caprolactones.Keywords
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