‘VA’, a New Type of Erythrocyte Poly agglutination Characterized by Depressed H Receptors and Associated with Hemolytic Anemia

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Abstract
With the help of immunofluorescence (best observed with anti-AHP [agglutinin] from Helix pomatia) a stippled structure could be demonstrated on the patient''s red blood cells. An A-like receptor could be detected on the erythrocyte membrane of this group O patient. The reactive antigen was not a crypt antigen exposed by the action of neuraminidase. The same stippled fluorescence with anti-AHP was observed on the red blood cells of a patient suffering from hemolytic anemia induced by influenza A2 virus. In this case this virus was not responsible for polyagglutination. No virus or microorganism could be isolated from the patient''s blood. Also by immunofluorescence the weak expression of the H antigen could be demonstrated with an extract of Euonymus europaeus. EM of erythrocytes was normal. The neuraminic acid content and the electrophoretic mobility were decreased to a minor degree. No distinct cell populations could be observed.