Brain parenchymal density measurements by CT in demented subjects and normal controls.

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Abstract
Parenchymal density measurements of 14 regions of gray and white matter from each cerebral hemisphere were made from CT [computed tomography] scans of 25 subjects who had varying degrees of dementia as measured by a global Clinical Dementia Rating, and also from CT scans of 33 normal control subjects. There were few significant differences between the 2 groups in the mean density value for each of the regions examined, although several individual psychometric tests did correlate with density changes. For 6 regions in the cerebral cortex, and for 1 region in the thalamus of each hemisphere, no significant correlation between the gray-white matter density difference and dementia was found. There was a loss of the discriminability between the gray and white matter with an increase in the size of the ventricles. These findings may be attributed to the loss of white matter volume.

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