Note on Some Aspects of the Effect of Nucleates in Primary and Transplanted Rat Hepatomas

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Abstract
The activity of the dehydrogenase system in the tissue of transplanted hepatoma from the rat, as measured by the rate of decolorization of methylene blue, is much lower than in normal liver. On addition of Na nucleate of both ribose and desoxyribose types, the activity is raised in the hepatoma but slightly decreased in the normal tissue at low concns. of the nucleate. Higher concns. of dye and nucleate (doubling both) depressed activity in both tissue and hepatoma, but more in the latter. Desamination of the nucleates also differed in these tissues, being more active in the hepatoma than in the normal tissue. In contrast, when-tissue from primary hepatomas (induced by ingestion of p-dimtethylaminoazobenzene) was compared with normal liver in the same way all these enzymatic activities were almost identical. The possible implications of these findings are discussed.

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