Ring Closing Metathesis for the Asymmetric Synthesis of (S)-Homopipecolic Acid, (S)-Homoproline and (S)-Coniine

1 July 2002

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 2002 (07) , 1146-1148
https://doi.org/10.1055/s-2002-32580

Abstract

Diastereoselective conjugate addition of lithium (S)-N-allyl-N-α-methylbenzylamide to α,β-unsaturated esters or Weinreb amides, followed by ring closing metathesis is used to afford the cyclic β-amino acids (S)-homopipecolic acid and (S)-homoproline and the amine (S)-coniine in high ee.

Keywords

LITHIUM AMIDE
CONJUGATE ADDITION
RING CLOSING METATHESIS
ASYMMETRIC SYNTHESIS
CYCLIC Β-AMINO ACIDS

This publication has 0 references indexed in Scilit: