The Cellular Functions of Small GTP-Binding Proteins
- 10 August 1990
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 249 (4969) , 635-640
- https://doi.org/10.1126/science.2116664
Abstract
A substantial number of novel guanine nucleotide binding regulatory proteins have been identified over the last few years but the function of many of them is largely unknown. This article will discuss a particular family of these proteins, structurally related to the Ras oncoprotein. Approximately 30 Ras-related small guanosine triphosphate (GTP)-binding proteins are known, and from yeast to man they appear to be involved in controlling a diverse set of essential cellular functions including growth, differentiation, cytoskeletal organization, and intracellular vesicle transport and secretion.Keywords
This publication has 84 references indexed in Scilit:
- A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteinsFEBS Letters, 1990
- Demonstration of GTP-binding proteins and ADP-ribosylated proteins in rat liver Golgi fractionBiochemical and Biophysical Research Communications, 1989
- The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants.The Journal of cell biology, 1989
- Rabbit intestine contains a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding proteinBiochemical and Biophysical Research Communications, 1989
- Kinetic analysis of the binding of guanine nucleotide to bovine brain smg p25ABiochemical and Biophysical Research Communications, 1989
- The C-terminal part of a gene partially homologous to CDC25 gene suppresses the cdc25-5 mutation in Saccharomyces cerevisiaeGene, 1989
- A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeastCell, 1988
- Study of a temperature-sensitive mutant of the ras-related YPT1 gene product in yeast suggests a role in the regulation of intracellular calciumCell, 1988
- Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteinsCell, 1985
- The role of guanosine 5′-triphosphate in polypeptide chain elongationBiochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics, 1978