Diodrast transit time in guinea pig biliary tree

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Abstract
Iodopyracet-I131 (Diodrast) was used to examine the relationship between transit time and flow in the biliary tree of the cholecystectomized guinea pig. Important features of Diodrast were efficient hepatic extraction, incomplete binding to serum proteins, and limited accumulation in hepatic cells. Its transit time was less than half the value obtained with Brom -sulphalein or rose bengal. When bile flow was increased threefold by giving sodium dehydrocnolate, Diodrast transit time declined only slightly. Consequently, the apparent volume of the biliary tree Increased with bile flow, a result not attributable to alterations in capacity as judged by measurements of the pressure-volume curve of the biliary tree. Equivalent estimates of transit time were obtained with tracer amounts of Diodrast and with large doses. Analysis of transfer kinetics and a mathematical model of the biliary tree are used to examine the possibility that alterations in apparent volume were principally the result of distal fluid transfer by the epithelium of interlobular ducts.