Morphine-like properties of diphenylethylamine and related compounds
- 10 April 1944
- journal article
- research article
- Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences
- Vol. 132 (867) , 119-132
- https://doi.org/10.1098/rspb.1944.0007
Abstract
Since morphine possesses the phenanthrene ring structure, experiments have been performed to investigate the possibility of producing a simple analogue with a relationship similar to that between oestrone and stilboestrol. The activity of diphenylethylamine and a number of other compounds has been investigated. Many were found to possess morphine-like activity, and of these the most promising from the clinical point of view was β -hydroxy- αβ -diphenylethylamine. This substance was found to give complete relief from pain in doses of 200-400 mg. 4-hourly.This publication has 1 reference indexed in Scilit:
- CLINICAL EFFECTIVENESS AND SAFETY OF A NEW SYNTHETIC ANALGESIC DRUG, DEMEROLArchives of internal medicine (1960), 1943