Experimental animal model of surgical wound infection applicable to antibiotic prophylaxis
- 1 October 1983
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 2 (5) , 459-462
- https://doi.org/10.1007/bf02013904
Abstract
Wound infection, defined as accumulation of pus draining spontaneously or after opening of the Wound, developed in 19 out of 22 guinea pigs (86 %) after intraincisional contamination with 107 Escherichia coli plus 108 Bacteroides fragilis before wound closure. Antibiotic prophylaxis with gentamicin plus clindamycin significantly reduced the wound sepsis rate from 86 % to 29 % (pEscherichia coli andBacteroides fragilis. The animal model Presented employs widely accepted criteria for wound infection, and avoids culture of tissue homogenates.Keywords
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