Novel lactone compounds from Mortierella verticillata that induce the human low density lipoprotein receptor gene: fermentation, isolation, structural elucidation and biological activities.
Open Access
- 1 January 1998
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 51 (1) , 14-20
- https://doi.org/10.7164/antibiotics.51.14
Abstract
Among methods of controlling hypercholesterolemia and hyperlipidemia is the direct stimulation of hepatic low density lipoprotein (LDL) receptors. Two novel lactone compounds, CJ-12, 950 and CJ-13, 357, containing an unusual oxime moiety, were isolated from a zygomycete Mortierella verticillata. These lactones are potent inducers of the LDL receptor gene in vitro, that enhanced LDL receptor expression in human hepatocytes 2-fold at 100nM.Keywords
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