Inhibition of Insulin Secretion by Aryl-substituted Secondary Aminoethanols
- 1 May 1969
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 18 (5) , 262-267
- https://doi.org/10.2337/diab.18.5.262
Abstract
The administration of glucose, tolbutamide, ACTH, and glucagon to mice resulted in increase of plasma insulin levels. These increases were all inhibited by the prior administration of aryl-substituted secondary aminoethanols (ASAE). Cyclic 3′,5′ AMP resulted in increased levels of plasma insulin in intact mice, and this stimulatory effect was also inhibited by the aryl-substituted secondary aminoethanols. The locus of the inhibitory effect of these compounds on insulin secretion is discussed.Keywords
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