The Development of the Blood-CSF Barrier after Birth
- 1 May 1976
- journal article
- research article
- Published by Georg Thieme Verlag KG in Neuropediatrics
- Vol. 7 (02) , 175-181
- https://doi.org/10.1055/s-0028-1091621
Abstract
The serum/CSF concentration ratio of α2-macroglobulin is used as parameter to follow the development of the blood-CSF barrier throughout childhood. The decline of the protein permeability within the first year of life has all characteristics of a maturation process. The tightening of the barrier is thought to be the last stage of a continuous developmental process of capillaries. It is accompanied by a compositional shift in favour of small molecular serum proteins. Der Serum/CSF Konzentrationsgradient des α2-Makroglobulins wird als Parameter benutzt, die Entwicklung der Blut-Liquor-Schranke während der Kindheit zu verfolgen. Die abfallende Proteinpermeabilität hat alle Charakteristiken eines Reifungsprozesses. Die Abdichtung der Schranke wird als letzte Phase einer kontinuierlichen Entwicklung der Kapillaren gedeutet. Sie ist begleitet von einer Verschiebung der Liquorzusammensetzung zugunsten kleinmolekularer Serumproteine.Keywords
This publication has 2 references indexed in Scilit:
- Distribution of the extracellular space during postnatal maturation of rat cerebral cortexThe Anatomical Record, 1968
- Serum α2-macroglobulin concentration and its variation with age and sexClinica Chimica Acta; International Journal of Clinical Chemistry, 1967