Hydrochlorothiazide Lowers Urinary Hydroxyproline in Parathyroidectomized Rats
- 1 January 1985
- journal article
- research article
- Published by Georg Thieme Verlag KG in Hormone and Metabolic Research
- Vol. 17 (01) , 50-51
- https://doi.org/10.1055/s-2007-1013450
Abstract
This study was undertaken to examine the effects of hydrochlorothiazide treatment on urinary hydroxyproline excretion in parathyroidectomized rats. Urinary hydroxyproline (μmol/24 hr) fell significantly in thiazide-treated rats compared with control animals (5.66 ± 0.37 versus 7.30 ± 0.6, P < 0.05, means ± SEM). This fall in hydroxyproline excretion occurred without a decrease in glomerular filtration rate. It is concluded that the ability of thiazide diuretics to reduce urinary hydroxyproline excretion is not dependent upon suppression of parathyroid hormone-mediated bone turnover.Keywords
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