The isolation, identification, and bioassay of the antifungal metabolites produced by Monocillium nordinii

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Abstract
The metabolites produced when M. nordinii (Bourchier) W. Gams, a destructive mycoparasite of pine stem rusts, is grown in liquid culture were separated and identified. The metabolites include the known compound monorden and 5 new substances, monocillin I, monocillin II, monocillin III, monocillin IV and monocillin V. Structural assignments and chemical correlations of the 5 new compounds are reported and the absolute configuration of monorden is assigned. The antifungal spectra of the 3 major metabolites are reported. Monorden and monocillin I show pronounced activity against a wide variety of fungi, including Ceratocystis ulmi, the cause of Dutch elm disease. Extraction of the mycelium yielded averufin along with a pigment C18H1206, as yet unidentified.