Estimation of cell damage in monolayer culture using 14C-leucine incorporation.
- 1 January 1977
- journal article
- research article
- Published by Tohoku University Medical Press in The Tohoku Journal of Experimental Medicine
- Vol. 121 (4) , 403-404
- https://doi.org/10.1620/tjem.121.403
Abstract
A comparison was made of 14C-leucine incorporation and cell viability of T24 human bladder carcinoma cells after treatment with Thio-Tepa, a potent alkylating agent. It was found that Thio-Tepa produced concentration-dependent damage in these cells and also that 14C-leucine incorporation cor-related well with cell viability. 114C-leucine incorporation can be used as a reliable and rapid screening test for the assessment of the relative potencies of anticancer drugs.Keywords
This publication has 1 reference indexed in Scilit:
- Specific Cytotoxicity In Vitro of Lymphocytes Sensitized in Culture Against Tumor CellsJNCI Journal of the National Cancer Institute, 1976