In-vitro antibacterial activity of Scb 25393, a fluorinated analogue of thiamphenicol

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Abstract
The in-vitro antibacterial activity of a fluorinated analogue of thiamphenicol, Sen 25393, has been evaJuated in comparison with chloramphenicol and thiamphenicol. The substitution of an hydroxyl group at position 3 and of two atoms of chlorine with fluorine in the acyl side-chain improves remarkably the antibacterial activity of the compound against strains resistant to chloramphenicol and thiamphenicol because of the production of acetyltransferases, but not against strains resistant because of non-enzymatic mechanisms of resistance. Although itself resistant to the enzymatic inactivation, Sch 25393 is unable to inhibit the acetylation of chloramphenicol and thiamphenicol.

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