Chronic morphine-induced hyperactivity in rats is altered by nucleus accumbens and ventral tegmental lesions
- 1 March 1984
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 82 (4) , 318-321
- https://doi.org/10.1007/bf00427677
Abstract
Lesions of the nucleus accumbens (NA) and the ventral tegmental area (VTA) attenuated and delayed the onset of the locomotor excitatory effects of morphine following chronic administration. Neither lesion, however, totally prevented the increase in locomotor excitation. These findings suggest that while the NA and VTA seem to play a role in mediating the excitatory effects of morphine, other regions and brain circuits must also be involved.Keywords
This publication has 15 references indexed in Scilit:
- Interactions between d-Ala-Met-enkephalin, A10 dopaminergic neurones, and spontaneous behaviour in the ratBehavioural Brain Research, 1980
- Biochemical mapping of the noradrenergic ventral bundle projection sites: Evidence for a noradrenergic-dopaminergic interactionBrain Research, 1979
- Stimulant effects of enkephalin microinjection into the dopaminergic A10 areaNature, 1979
- Immunohistochemical localization of enkephalin in rat brain and spinal cordJournal of Comparative Neurology, 1978
- Nucleus accumbens lesions reduce amphetamine hyperthermia but not hyperactivityEuropean Journal of Pharmacology, 1978
- Determination of methionine enkephalin in discrete regions of rat brainBrain Research, 1977
- Neuroanatomical focus for morphine and enkaphalin-induced hypermotilityNature, 1977
- CATECHOLAMINES IN FETAL AND NEWBORN RAT BRAINJournal of Neurochemistry, 1973
- Time‐dose relationships for locomotor activity effects of morphine after acute or repeated treatmentBritish Journal of Pharmacology, 1972
- Lesions in the nuclei accumbens septi of the rat: Behavioral and neurochemical effects.Journal of Comparative and Physiological Psychology, 1970