Plasmacytomas of the NZB Mouse
Open Access
- 1 November 1978
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 121 (5) , 1969-1972
- https://doi.org/10.4049/jimmunol.121.5.1969
Abstract
Plasmacytomas were readily induced in NZB mice by three i.p. inoculations with pristane (2, 6, 10, 14-tetramethylpentadecane). In comparison with comparable induction regimens in BALB/c mice a) the latent period for plasmacytoma development was significantly longer in NZB's; b) the frequency of IgA paraproteins produced by NZB tumors was much reduced and that of IgG (IgG1, IgG2a, IgG2b, IgG3) was significantly increased; and c) the frequency of carbohydrate-binding paraproteins was 10-fold lower. There was a high frequency of primary ascites containing more than one paraprotein, but none of 25 such tumors produced more than one immunoglobulin class on serial transplantation.Keywords
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