p38 MAPK is involved in CB2 receptor‐induced apoptosis of human leukaemia cells
- 25 August 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (22) , 5084-5088
- https://doi.org/10.1016/j.febslet.2005.08.021
Abstract
Cannabinoids have been shown to inhibit the growth of a broad spectrum of tumour cells. However, the molecular mechanisms involved in that effect have not been completely elucidated. Here, we investigated the possible involvement of mitogen-activated protein kinases (MAPKs) in CB2 receptor-induced apoptosis of human leukaemia cells. Results show that stimulation of the CB2 receptor leads to p38 MAPK activation and that inhibition of this kinase attenuates CB2 receptor-induced caspase activation and apoptosis. These findings support a role for p38 MAPK in CB2 receptor-induced apoptosis of human leukaemia cells.Keywords
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