Cardiac Cellular Potentials: Effect of Vagal Stimulation and Acetylcholine

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Abstract
The technic of intracellular micro-electrode recording has been employed to study the effect of vagal stimulation and acetylcholine on the membrane potentials of the dog''s heart, both in situ and in isolation. Vagal stimulation produces a great increase in the rate of repolarization of auricular fibers without producing any decrease in the magnitude of either the resting potential or action potential. Acetylcholine has a similar effect to vagal stimulation, whether injected into the intact animal or applied to the isolated auricle. Acetylcholine is without effect on the membrane potentials of the intact ventricle or the isolated papillary muscle. A preliminary hypothesis concerning the nature of the delayed repolarization of cardiac tissue, and the mode of action of acetylcholine thereon, has been advanced.

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