Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis
Top Cited Papers
- 1 April 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 6 (4) , 345-351
- https://doi.org/10.1038/nrm1620
Abstract
Iron-sulphur clusters are important cofactors for proteins that are involved in many cellular processes, including electron transport, enzymatic catalysis and regulation. The enzymes that catalyse the formation of iron-sulphur clusters are widely conserved from bacteria to humans. Recent studies in model systems and humans reveal that iron-sulphur proteins have important roles in mitochondrial iron homeostasis and in the pathogenesis of the human disease Friedreich ataxia.Keywords
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