Immunosuppression of the Antibody Response to Respiratory Syncytial Virus (RSV) by Pre-existing Serum Antibodies: Partial Prevention by Topical Infection of the Respiratory Tract with Vaccinia Virus-RSV Recombinants
- 1 August 1989
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 70 (8) , 2185-2190
- https://doi.org/10.1099/0022-1317-70-8-2185
Abstract
Immunization strategies to prevent respiratory syncytial virus (RSV) disease will involve immunization of infants less than 2 months of age who possess maternally derived RSV antibodies. Vaccinia-RSV recombinant viruses are useful tools for defining parameters important in immunization against RSV and also are being considered as live virus vaccines for use in humans. Previous studies demonstrated that passively acquired RSV antibodies can suppress the immune response and the protective efficacy of vaccinia-RSV recombinants administered by the intradermal route. The present study demonstrates that the suppressive effects of passively acquired antibody on immunity induced by intradermally administered vaccinia-RSV recombinants in cotton rats can be partially overcome by administration of the recombinants by the intranasal route.This publication has 14 references indexed in Scilit:
- Local and systemic antibody response to bovine respiratory syncytial virus infection and reinfection in calves with and without maternal antibodiesJournal of Clinical Microbiology, 1987
- Glycoproteins of Human Parainfluenza Virus Type 3: Affinity Purification, Antigenic Characterization and Reconstitution into Lipid VesiclesJournal of General Virology, 1987
- Expression of the fusion protein of human respiratory syncytial virus from recombinant vaccinia virus vectors and protection of vaccinated miceJournal of Virology, 1987
- Human and murine cytotoxic T cells specific to respiratory syncytial virus recognize the viral nucleoprotein (N), but not the major glycoprotein (G), expressed by vaccinia virus recombinants.The Journal of Immunology, 1986
- Effect of age and preexisting antibody on serum antibody response of infants and children to the F and G glycoproteins during respiratory syncytial virus infectionJournal of Clinical Microbiology, 1986
- Human respiratory syncytial virus glycoprotein G expressed from a recombinant vaccinia virus vector protects mice against live-virus challengeJournal of Virology, 1986
- Expression of the F glycoprotein of respiratory syncytial virus by a recombinant vaccinia virus: comparison of the individual contributions of the F and G glycoproteins to host immunity.Proceedings of the National Academy of Sciences, 1986
- Dissociation between serum neutralizing and glycoprotein antibody responses of infants and children who received inactivated respiratory syncytial virus vaccineJournal of Clinical Microbiology, 1986
- Serum and nasal-wash immunoglobulin G and A antibody response of infants and children to respiratory syncytial virus F and G glycoproteins following primary infectionJournal of Clinical Microbiology, 1986
- Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virusJournal of Virology, 1986