Herpetic Virus in Mice: Pathogenicity, Immunity and Susceptibility of the Host

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Abstract
2 strains of herpetic virus were used on white mice,[long dash]J. B. virus proving more virulent than the Levaditi, by cutaneous inoculation. Male mice showed a greater susceptibility than females to cutaneous inoculation of J. B. virus. Formaldehyde and HNO3 destroyed the virus at site of inoculation. Immunity was produced after tail inoculation, even though encephalitis occasionally appeared. This immunity lasted for a variable time. Intraperitoneal injections of formaldehyde suspension of brain infected with J. B. virus produced immunity and the virus was still living in the solution (0.2% formaldehyde). Feeding of thyroid gland and acid showed a definite increase in susceptibility to J. B. virus administered subcu-taneously or intraperitoneally.

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