Chromosome 2 Sequence of the Human Malaria ParasitePlasmodium falciparum
- 6 November 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 282 (5391) , 1126-1132
- https://doi.org/10.1126/science.282.5391.1126
Abstract
Chromosome 2 ofPlasmodium falciparumwas sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with theSaccharomyces cerevisiaegenome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-richP. falciparumgenome is technically feasible.Keywords
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