POLIODYSTROFIA CEREBRI PROGRESSIVA INFANTILISAn entity?

Abstract
Case histories and findings at autopsy of the brains in 7 infants with progressive encephalopathy are presented. The clinical course of the disease was rather uniform, much reminding of the infantile types of leucodystrophia. Examination of the central nervous system revealed mainly involvement of the cortical grey matter exclusively. Here the picture is marked by status spongiosus including laminary necrosis, degeneration of ganglion cells, and glial proliferation. Irrespective of the theories prevailing for the time being we find it reasonable to uphold the contention of poliodystrophia being a nosological entity.

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