Recombinant Interleukin-4 Enhances the Chemiluminescent Oxidative Burst of Murine Peritoneal Macrophages
- 1 June 1991
- journal article
- research article
- Published by Wiley in Journal of Leukocyte Biology
- Vol. 49 (6) , 587-591
- https://doi.org/10.1002/jlb.49.6.587
Abstract
We evaluated the effects of murine recombinant interleukin-4 (rIL-4) on murine peritoneal macrophages. We showed a marked, dose-dependent stimulation of respiratory oxidative burst by IL-4 in peptone-elicited murine peritoneal macrophages. This effect was abolished by a neutralizing monoclonal antibody (mAb) to rlL-4 confirming that the enhanced chemiluminescence was due to IL-4. In contrast, rlL-4 depressed the respiratory oxidative burst of a transformed murine macrophage cell line, J774, in a dose-dependent mAb-reversible manner.Keywords
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