Possible mechanisms underlying the special vulnerability of dopaminergic neurons
- 1 October 1991
- journal article
- review article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 84 (S136) , 16-18
- https://doi.org/10.1111/j.1600-0404.1991.tb05014.x
Abstract
Endogenous or exogenous agents may account for the special vulnerability of dopaminergic neutrons. The present paper deals primarily with the possible role of toxic quinoid metabolites of catechols formed by autoxidation. The study of 5-S-cysteinyl adducts of these metabolites may provide clues to underlying mechanisms. In addition these adducts may serve as markers of Parkinson's disease.Keywords
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