Effect of Erythropoietin and Oxygen Tension on in vitro Synthesis of Hemoglobin A and F by Adult Human Bone Marrow.
- 1 August 1965
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 119 (4) , 1207-1210
- https://doi.org/10.3181/00379727-119-30415
Abstract
Summary Hemoglobin F and A synthesis was studied in in vitro suspensions of normal adult human bone marrow. Hb A synthesis continued throughout the 7 2-hour period whereas Hb F synthesis ceased after 24 hours. Erythropoietin, added in vitro, stimulated total hemoglobin synthesis without affecting Hb F synthesis. Hypoxia depressed total globin synthesis without affecting Hb F synthesis. Thus the synthesis of Hb A and F appears to respond independently to environmental stimuli.This publication has 4 references indexed in Scilit:
- Regulation of Erythropoiesis. XV. Neonatal Erythropoiesis and the Effect of Nephrectomy *Journal of Clinical Investigation, 1964
- In VitroStudies on the Effect of Erythropoietin on Glucosamine-l-14C Incorporation Into Rat Bone Marrow CellsEndocrinology, 1964
- The Effect of Erythropoietin upon Heme Synthesis by Marrow Cells in VitroJournal of Biological Chemistry, 1963
- FACTORS INFLUENCING RELATIVE RATES OF SYNTHESIS OF ADULT AND FETAL HEMOGLOBIN IN VITRO*Journal of Clinical Investigation, 1960