PREPARATION AND METABOLISM OF IODINATED PEPTIDES1
- 1 May 1960
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 66 (5) , 669-675
- https://doi.org/10.1210/endo-66-5-669
Abstract
A method of preparation and of I131 - labeling of L-leucyl-L-mono- or diiodotyrosine, and glycyl-L-mono- or diiodotyrosine is described. Studies with sheep thyroid and liver have been performed. A peptidase which hydrolyzes the iodinated dipeptides is present in liver and thyroid microsomes and in the cell sap of these preparations. A tissue deiodinase was also demonstrated, but it could not be shown that this was active prior to hydrolysis of the dipeptide.Keywords
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