Increased ATP-ase Activity of Lymphocytes after Rosette Formation with Sheep Red Blood Cells

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Abstract
In a number of experiments it was demonstrated that in the E[erythrocyte]-rosette assay for human T[thymus-derived]-lymphocytes using sheep red blood cells SRBC, the ATPase activity of the lymphocytes increased in proportion to the number of rosettes being formed. Also, after increasing the number of rosettes by treatment of the SRBC with neuraminidase and after diminishing the number of rosettes by treatment of the lymphocytes with antilymphocyte globulin (ALG), change in the ATPase activity was proportional to alterations in the number of rosettes being formed. ALG itself stimulated the lymphocyte ATPase activity, possibly through activation of the same receptor sites as used by SRBC.