A Standardized Test of Platelet Adhesiveness

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Abstract
Zacharski, Leo R., and McIntyre, O. Ross: A standardized test of platelet adhesiveness. Am. J. Clin. Pathol. 58: 422–427, 1972. An inexpensive and easily constructed glass bead column for determining adhesiveness in vitro is described. The column consists of a flexible paper sipping straw to which a measured quantity of glass beads is added. The column is perfused with heparinized blood at a constant rate of flow. The median platelet adhesiveness in a defined population of normal adults was 74% and the range of normal was 35 to 94%. This test is capable of clearly demonstrating the defect in platelet adhesiveness characteristic of von Willebrand’s disease. The test is normal in classic hemophilia. Availability of this simplified column should facilitate the diagnostic and investigative application of the in vitro platelet adhesiveness test.

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