Oxidation of N-acyl-pyrrolidines and -piperidines with lron(II)-hydrogen peroxide and an iron complex-molecular oxygen
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 6,p. 1259-1262
- https://doi.org/10.1039/p19870001259
Abstract
The reactions of N-acyl-pyrrolidines (1a–c) and -piperidines (1d–f) with FeII-hydrogen peroxide in aqueous 95% acetonitrile gave the corresponding pyrrolidin-2-ones (2a–c) and piperidin-2-ones (2d–f). The lactams (2a–f) were also the products in the oxidation of (1a–f) with molecular oxygen in the presence of an iron complex, either [FeIIFeIII 2O(OAc)6(py)3] or [{Fe(salen)}2O], in aqueous 90% pyridine.Keywords
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