The mechanism of the inhibition of dehydrogenases by salicylate
- 1 June 1967
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 19 (6) , 355-366
- https://doi.org/10.1111/j.2042-7158.1967.tb09561.x
Abstract
Salicylate inhibits rabbit muscle lactate dehydrogenase, horse liver alcohol dehydrogenase, pig heart malate dehydrogenase and pig heart isocitrate dehydrogenase in vitro. The inhibitions are reversible, involving competition with nad, nadh2 or nadp. The results are discussed with reference to some of the in vivo actions of the drug.This publication has 21 references indexed in Scilit:
- Beef Heart Malic DehydrogenasesPublished by Elsevier ,1966
- THE ACTIVITY OF LIVER ALCOHOL DEHYDROGENASE WITH NICOTINAMIDE-ADENINE DINUCLEOTIDE PHOSPHATE AS COENZYMEBiochemical Journal, 1965
- Rat Liver Lactate DehydrogenaseJournal of Biological Chemistry, 1964
- Inhibition of Dehydrogenases by SalicylateNature, 1964
- Effects of salicylate, γ-resorcylate and gentisate on oxidase enzyme systems from guinea-pig liver mitochondriaBiochemical Pharmacology, 1963
- Effects of salicylate and γ-resorcylate on the metabolism of radioactive succinate and fumarate by rat-liver mitochondria and on dehydrogenase enzymesBiochemical Journal, 1963
- Effect of Salicylate on Blood and Liver Xanthine Dehydrogenase of RatsNature, 1959
- Initial Steady State Velocities in the Evaluation of Enzyme-Coenzyme-Substrate Reaction Mechanisms.Acta Chemica Scandinavica, 1957
- Some properties of purified isocitric enzymeBiochemical Journal, 1956
- Effect of Sodium Salicylate and Acetylsalicylate on Metabolism of Rat Brain and Liver in VitroAmerican Journal of Physiology-Legacy Content, 1951