Joint involvement in patients with severe haemophilia A in 1957–59 and 1978–79

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Abstract
Summary.: Clinical findings of joint involvement in patients with severe haemophilia A were compared between two surveys made in 1957‐59 and 1978–79. Permanent joint changes were seen in 50 (81%) of 62 patients in 1957‐59 and in 70 (86%) of 81 patients in 1978–79. The incidence of permanent changes was the same in the two surveys in all 10‐year age groups, but the degree of involvement was less severe in the two youngest age groups in 1978–79. It is concluded that effective replacement therapy can delay but not prevent completely the development of progressive arthropathy in patients with severe haemophilia A.