Effects of Vaccination for Marek's Disease on Growth of a Marek's-Virus-Induced Transplantable Lymphoma in Syngeneic and Allogeneic Chickens

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Abstract
The effects of vaccination with turkey herpesvirus on the growth of tumors following inoculation of lymphoma cells induced by Marek''s disease virus (MDV) were studied. The cells used were from a transplantable MDV-induced lymphoid tumor (MDT-198) maintained by passaging in syngeneic hosts. Vaccination did not prevent progressive tumor growth or alter subsequent mortality among syngeneic recipients of MDT-198 cells. With allogeneic recipients, vaccination had a significant protective effect in that progressive tumor growth and mortality were markedly lowered. Both development of visceral lymphomas and atrophy of thymus and bursa were found at necropsy in syngeneic and allogeneic hosts when progressive tumor growth occurred at the site of inoculation. The primary and effective component of turkey-herpesvirus-induced protection against Marek''s disease is probably not directed against Marek''s-disease-tumor-specific antigens.

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