Unprecedented Acceleration of Zirconium(IV)-Assisted Peptide Hydrolysis at Neutral pH
- 2 September 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Inorganic Chemistry
- Vol. 43 (20) , 6130-6132
- https://doi.org/10.1021/ic049433j
Abstract
4,13-Diaza-18-crown-6 substantially increases the rate of zirconium(IV) hydrolysis of unactivated peptide amide bonds under near-physiological conditions of temperature and pH. In the presence of this azacrown ether, ZrCl4 efficiently hydrolyses both neutral and negatively charged peptides (pH 7.0−7.3, 37−60 °C).Keywords
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