A novel mutation that affects utilization of galactose in Saccharomyces cerevisiae
- 1 October 1980
- journal article
- Published by Springer Nature in Current Genetics
- Vol. 2 (2) , 115-120
- https://doi.org/10.1007/bf00420623
Abstract
A novel type of regulatory mutation for galactose metabolism in Saccharomyces cerevisiae is described. The mutation named gal11 was recessive, non-allelic to GAL4, GAL80, GAL2, or GAL3, and unlinked to the gene cluster of GAL1, GAL10, and GAL7. It caused a ‘coordinate’ reduction of galactokinase, galactose-1-P uridylyl transferase, and UDP-glucose 4-epimerase by a factor of more than 5, rendering the mutant cells galactose-nonfermenting. The effect of the mutation was manifested not only in cells grown on galactose but also in cells constitutively synthesizing the galactose-metabolizing enzymes.Keywords
This publication has 22 references indexed in Scilit:
- The enzymes of the galactose cluster in Saccharomyces cerevisiae. II. Purification and characterization of uridine diphosphoglucose 4-epimerase.Journal of Biological Chemistry, 1980
- Constitutive synthesis of the GAL4 protein, a galactose pathway regulator in saccharomyces cerevisiaeCell, 1979
- Regulation of the galactose pathway in Saccharomyces cerevisiae : Induction of uridyl transferase mRNA and dependency on GAL4 gene functionProceedings of the National Academy of Sciences, 1978
- Interaction of super-repressible and dominant constitutive mutations for the synthesis of galactose pathway enzymes in Saccharomyces cerevisiaeMolecular Genetics and Genomics, 1977
- REGULATION OF GENES CONTROLLING SYNTHESIS OF THE GALACTOSE PATHWAY ENZYMES IN YEASTGenetics, 1966
- ENZYMATIC EXPRESSION AND GENETIC LINKAGE OF GENES CONTROLLING GALACTOSE UTILIZATION IN SACCHAROMYCESGenetics, 1964
- A gene controlling inducibility of the galactose pathway enzymes in SaccharomycesBiochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects, 1963
- Mécanismes régulateurs dans la biosynthèse des enzymes du métabolisme du galactose chez Escherichia coli K12Journal of Molecular Biology, 1963
- A mutation in saccharomyces that affects phosphoglucomutase activity and galactose utilizationBiochimica et Biophysica Acta, 1961
- DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTIONJournal of Biological Chemistry, 1949