Phototoxicity of chlorpromazine
- 31 January 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (2) , 202-204
- https://doi.org/10.1021/jm00188a016
Abstract
The constitution of chlorpromazine was studied in the context of its phototoxicity. Electron transfer from the side chain to the aromatic nucleus of the drug contributes to its instability to light. Even without the side chain, however, chlorophenothiazines appear to be very photolabile, so that it is unlikely that nonphototoxic analogs of chlorpromazine can be prepared merely by altering the constitution of the side chain.This publication has 0 references indexed in Scilit: