An Effect of Tolbutamide on Nucleotides of Incubated Whole Human Blood.

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Abstract
Fresh human blood collected in heparin and glucose was incubated without and with tolbutamide for up to 48 hours. The blood nucleotides were determined by column chromatography. The levels of ATP in the tolbutamide samples were less than in the control samples and the levels of ATP breakdown products were higher although glucose utilization appeared to be unaffected by the tolbutamide. It was concluded that the changes in the blood nucleotide pattern were more subtle indicators of the effects of tolbutamide on energy metabolism than more conventional measures such as glucose utilization but the implications of the findings are not entirely clear.

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