Preparation of Imino and Amino N-15 Enriched 2-Aminopurine Deoxynucleoside

1 January 1989

journal article
research article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 8 (1) , 23-34
https://doi.org/10.1080/07328318908054155

Abstract

We report the synthesis of N-15 enriched 2-aminopurine-2''-deoxynucleoside (APdR). Both ring and 2-amino nitrogens were labelled via a Dimroth rearrangement of the free base. The corresponding deoxynucleoside was prepared enzymatically. Results of both proton and N-15 NMR studies show that studies show that the predominant tautomeric form of APdR is amino and the N1 position is shown to be the site of protonation.

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