Clinical Significance of Creatinine Measurements

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Abstract
Determining creatinine clearance is probably the best method available to most physicians for approximating the glomerular filtration rate. However, the methods of measurement used most often are based on the Jaffe reaction, which is not specific for creatinine. Creatinine is formed from creatine in muscle by an irreversible reaction. Clearance rates below 60 ml per minute are considered pathologic. Recent studies indicate that the creatinine level in amniotic fluid may predict fetal maturity.

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