In VitroInhibition of Pancreatic Glucagon Secretion by Diphenylhydantoin

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Abstract
Diphenylhydantoin (DPH) has been reported to stabilize poorly controlled insulin-dependent diabetes mellitus. Since this condition is characterized by elevated plasma levels of glucagon, the beneficial effect of DPH may be attributable to modification of glucagon release. To investigate this possibility, the effects of DPH on arginine-induced glucagon secretion were studied in the isolated perfused rat pancreas. At 25 μg/ml, DPH markedly diminished glucagon release and had no effect on insulin responses. Evidence is thus presented that DPH directly inhibits pancreatic glucagon secretion. These results suggest DPH may be of value for stabilization of poorly controlled diabetes mellitus.

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